CLDN 7 ( claudin 7 )
نویسندگان
چکیده
DNA/RNA Description 2573 base-pairs, starts at 7163223 and ends at 7165795 bp from pter with minus strand orientation. Transcription This gene contains 4 exons and 3 introns. The transcription produces 3 alternatively spliced mRNA variants: variant 1 (NM_001307.5) encodes the longer isoform; variant 2 (NM_001185022.1) has an alternate 5' UTR sequence; variant 3 (NM_001185023.1) lacks an exon in the 3' CDS. Pseudogene The sequence named LOC100129851 claudin 7 pseudogene is a pseudogene of Claudin 7 located at Xp11.4.
منابع مشابه
Development of an anti-claudin-3 and -4 bispecific monoclonal antibody for cancer diagnosis and therapy.
Most malignant tumors are derived from epithelium, and claudin (CLDN)-3 and CLDN-4 are frequently overexpressed in such tumors. Although antibodies have potential in cancer diagnostics and therapy, development of antibodies against CLDNs has been difficult because the extracellular domains of CLDNs are too small and there is high homology among human, rat, and mouse sequences. Here, we created ...
متن کاملDifferential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function.
Alveolar barrier function depends critically on the claudin family tight junction proteins. Of the major claudins expressed by alveolar epithelial cells, claudin (Cldn)-3 and Cldn-4 are the most closely related by amino acid homology, yet they differ dramatically in the pattern of expression. Previously published reports have shown that Cldn-3 is predominantly expressed by type II alveolar epit...
متن کاملExpression of claudin 1, claudin 4, and claudin 7 in colorectal cancer and its relation with CLDN DNA methylation patterns.
Altered claudin expression has been described in colon, prostatic, ovarian, and breast carcinoma. However, the role of epigenetic modifications in these genes and their role in colorectal cancer is unknown. We aimed our study to investigate whether claudin protein expression and methylation of CLDN can influence the tumorigenesis of colorectal cancer. A total of 31 patients diagnosed with color...
متن کاملTitle : Development of an anti - claudin - 3
This article has not been copyedited and formatted. The final version may differ from this version. Abstract Most malignant tumors are derived from epithelium, and claudin (CLDN)-3 and-4 are frequently overexpressed in such tumors. Although antibodies have potential in cancer diagnostics and therapy, development of antibodies against CLDNs has been difficult because the extracellular domains of...
متن کاملCellular networks of human thymic medullary stromas coordinated by p53-related transcription factors.
The final elimination step of self-reactive T cells occurs in the medulla of the thymus where a complex framework provided by stromal cells supports an optimal milieu for their selection. Here we present evidence that tight junctions (TJs) widely join medullary stromal cells of the human thymus. Occludin (OCLN) and claudin-1 (CLDN-1) of TJ-associated molecules were dominantly expressed in medul...
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